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The Science Behind GlycoCarn® Nitric Oxide Booster

Scientific studies show that GlycoCarn® is a highly effective nitric oxide booster. In fact, recent double blind studies reveal that GlycoCarn is the only ingredient proven to increase nitric oxide levels in the human bloodstream.

GlycoCarn is glycine propionyl-L-carnitine hcl, (GPLC), a propionyl ester of carnitine that includes an additional glycine component. Compared with other forms of carnitine, GlycoCarn works as a nitric oxide booster, exhibiting a special affinity for muscle tissues, such as the heart. In addition it helps boost nitric oxide health, acting as a powerful scavenger against superoxide radicals, and protects against lipid peroxidation.

GlycoCarn Nitric Oxide Booster Disclaimer

GlycoCarn Encourages Nitric Oxide Health

GlycoCarn, (Sigma-tau HealthScience brand of glycine propionyl-L-carnitine hcl, (GPLC), is a next generation member of the L-Carnitine family, with a particular focus on offering nitric oxide health benefits to skeletal muscle, cardiac tissue, and the vascular system. Carnitine in general is known to be involved in fatty acid metabolism, and GlycoCarn is a patented compound that has been shown to result in an increase in blood levels of nitric oxide, as well as delivering potent antioxidant properties. Ongoing research indicates that along with its ability to be a nitric oxide booster, this compound may be associated with improved high intensity exercise performance. The performance effects of GlycoCarn may be a result of both its nitric oxide boosting properties as well as its antioxidant activity, ultimately leading to increased blood flow and enhanced ATP energy production.

The applications for GlycoCarn continue to be revealed, as funded research with this compound is presently ongoing at universities within the United States.

Look for GlycoCarn, the nitric oxide booster that encourages blood flow and delivers antioxidant properties. Contact us to learn how to enhance your existing supplement with our powerful formulation.





Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with
reduced lactate accumulation in resistance trained males

Recent research has indicated that short term administration of glycine propionyl-L-carnitine (GPLC) significantly elevates levels of nitric oxide metabolites at rest and in response to reactive hyperaemia. However, no scientific evidence exists that suggests such supplementation enhances exercise performance in healthy, trained individuals. The purpose of this study was to examine the effects of GPLC on the performance of repeated high intensity stationary cycle sprints with limited recovery periods in resistance trained male subjects... (read more)



Glycine Propionyl-L-Carnitine Increases Plasma Nitrate/Nitrite in Resistance Trained Men

We have recently demonstrated that oral intake of glycine propionyl-L-carnitine (GPLC) increases plasma nitrate/nitrite (NOx), a surrogate measure of nitric oxide production. However, these findings were observed at rest, and in previously sedentary subjects... (read more)



The Efficacy of Dietary Supplementation for Enhanced Nitric Oxide Synthesis: The Scientific Evidence

Approximately twenty years ago, it was discovered that a particular factor produced within endothelial tissue specifically relaxes the adjacent smooth muscle of blood vessels thereby allowing vasodilation and increased blood flow to various tissues including skeletal muscle. This factor was initially referred to as endothelium-derived relaxing factor but is now known as nitric oxide... (read more)



GPLC - The Scientific Research in Determining its Impact

Hundreds if not thousands of new sport supplements are introduced each year, many of which have little or no scientific evidence of effect. More importantly, based on the relevant biochemistry and the suggested recommended dosage provided by the manufacturer, there is little reason to believe that many of these products would have any meaningful effect. Rather, aggressive marketing campaigns, coupled with paid endorsements from top athletes (and a bit of “placebo” effect thrown in for good measure), catapult these products to the top of their respective class within months of being on the market... (read more)



Nitric Oxide Stimulating Dietary Supplements: Where is the Evidence?

Dietary supplements purported to increase nitric oxide production have gained enormous popularity within the athletic (e.g., bodybuilding) community in recent years. Although anecdotal reports suggest apotential benefit from using such products, the scientific evidence is sparse. To the knowledge of this author, only one ingredient consumed in oral form by human subjects has been reported within the scientific literature to promote an increase in blood nitric oxide. This ingredient is a unique form of L-carnitine called glycine propionyl-L-carnitine (GPLC)... (read more)



The Anabolic Pump Protocol: Top 6 Blood Flow Supplements

Let’s be honest: getting a big muscle pump looks and feels damn good. But vanity aside, it also has a spectacular side effect… anabolism! If you want to start maximizing your pump now, keep reading, because you’re about to discover the best supplements for doing just that. We all know that the pump is that amazing, albeit temporary, increase in muscle size we get while training. But what is it and how can we use it to achieve our goals? This muscle-swelling phenomenon is actually a localized increase in muscle blood flow used to deliver more nutrients and clear away waste. To understand why this is a big deal, consider the following... (read more)



Glycine Propionyl-L-Carnitine HCl (GPLC-GlycoCarn®): A Vasodilatory and Antioxidant Agent

Bodybuilders are constantly seeking methods to improve exercise performance and recovery. Aside from advanced training techniques, well-planned dietary strategies, optimal rest, and in some cases pharmaceutical assistance, the use of nutritional supplements is often considered paramount. This is because many products are currently available that appear to provide assistance in this regard. Some products contain new ingredients that are relatively unknown by those within the bodybuilding community. However, in some cases these new ingredients may be of great interest to bodybuilders, strength athletes, and general fitness enthusiasts. One such ingredient is Glycine Propionyl-L-Carnitine (GPLC) or GlycoCarn®... (read more)



Nitric Oxide Stimulating Dietary Supplements: Where is the evidence?

Dietary supplements purported to increase nitric oxide production have gained enormous popularity within the athletic (e.g., bodybuilding) community in recent years. Although anecdotal reports suggest a potential benefit from using such products, the scientific evidence is sparse. To the knowledge of this author, only one ingredient consumed in oral form by human subjects has been reported within the scientific literature to promote an increase in blood nitric oxide...(read more)



Glycine Propionyl-L-Carnitine (GPLC-GlycoCarn®) and Exercise Metabolism

Athletes and fitness enthusiasts are constantly looking for methods to improve exercise performance and to lose additional body fat. In this quest, individuals look towards advanced exercise training methods, dietary strategies, and nutritional supplements. Pertaining to the latter, several products are available, some with a substantial body of evidence in support of their use (e.g., creatine, caffeine), and many more with little to no evidence indicating beneficial effects on either exercise performance or body composition... (read more)



Dietary Glycine Propionyl-L-Carnitine HCl, (GPLC-GlycoCarn®) for Human Health and Performance

Dietary supplementation with the naturally occurring nutrient L-carnitine has been extensively studied as an aid to improve fatty acid metabolism and aerobic exercise capacity, to provide antioxidant benefits, and to enhance blood flow to active tissues (e.g., skeletal muscle and heart). While multiple forms of carnitine have been the focus of ongoing scientific study over the past several decades, and several are currently available for retail sale, Propionyl-L-Carnitine (PLC) has been shown to provide an optimal vasodilatory effect to blood vessels, and to support healthy heart and skeletal muscle function... (read more)



Glycine Propionyl-L-Carnitine HCL, (GlycoCarn®) for Human Health and Performance

Dietary supplementation with the naturally occurring nutrient L-carnitine has been extensively studied as an aid to improve fatty acid metabolism and aerobic exercise capacity, to provide antioxidant benefits, and to enhance blood flow to active tissues (e.g., skeletal muscle and heart). While multiple forms of carnitine have been studied and are currently available, Propionyl-L-Carnitine (PLC) has been shown to best support healthy heart and skeletal muscle function... (read more)



Global Challenges in Nutritional-Energy Inadequacy Create Enormous Opportunities For Effective Bio-Energetic Product Synergy

We are all integrally involved with the global systems of interdependence in financial complexities, population stabilities and the essential core requirement for individual health and wellness: Energy Sufficiency and Redox Balance, ie: Cellular ATP Supply and Oxidative/Reductive Stress Homeostasis. Whether individuals are involved in minimally, physically demanding activities or excessively high-output, physically-strenuous athletic performance, we all metabolically function optimally with adequate energy availability and effective intracellular Oxidative Balance... (read more)



Journal of the International Society of Sports Nutrition

We have recently demonstrated that oral intake of glycine propionyl-L-carnitine (GPLC) increases plasma nitrate/nitrite (NOx), a surrogate measure of nitric oxide production. However, these findings were observed at rest, and in previously sedentary subjects... (read more)




Nitric Oxide Stimulating Dietary Supplements: Introducing Glycine Propionyl-L-Carnitine (GPLC)

Nitric oxide (NO_), initially known as endothelium derived relaxing factor (EDRF), is biosynthesized within the body from L-arginine and oxygen by a variety of nitric oxide synthase enzymes... (read more)




Oxidative Stress and Exercise: Role of Glycine Propionyl-L-Carnitine (GPLC)

Oxidative stress occurs when the production of reactive oxygen species (ROS), often referred to as “free radicals”, exceeds antioxidant defense (Halliwell and Cross, 1994; Sies, 1997). The antioxidant system is comprised of both endogenous (within the body) and exogenous (outside of the body) defense mechanisms... (read more)





 

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